Abstract #2810

Paramagnetic Rim Lesions in MS are characterized by heterogeneous damage and inflammatory activity: a combined T1 relaxometry-diffusion study

Muhamed Barakovic^1,2,3, Riccardo Galbusera^1,2,3, Reza Rahmanzadeh^1,2,3, Matthias Weigel^1,2,3, Po-Jui Lu^1,2,3, Erik Bahn⁴, Simona Schiavi⁵, Alessandro Daducci⁵, Pascal Sati^6,7, Pietro Maggi^8,9, Ludwig Kappos^2,3, Jens Kuhle^2,3, Laura Gaetano¹⁰, Stefano Magon¹¹, and Cristina Granziera^1,2,3

¹Translational Imaging in Neurology (ThINk) Basel, University Hospital Basel and University of Basel, Basel, Switzerland, ²Neurologic Clinic and Policlinic, University Hospital Basel and University of Basel, Basel, Switzerland, ³Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB) Basel, University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Institute of Neuropathology, University Medical Center, Göttingen, Germany, ⁵Department of Computer Science, University of Verona, Verona, Italy, ⁶Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, ⁷Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁸Department of Neurology, Lausanne University Hospital, Lausanne, Switzerland, ⁹Cliniques universitaires Saint Luc, Université catholique de Louvain, Louvain, Belgium, ¹⁰F. Hoffmann-La Roche Ltd., Basel, Switzerland, ¹¹Pharmaceutical Research and Early Development, Roche Innovation Center Basel F. Hoffmann-La Roche Ltd., Basel, Switzerland

Paramagnetic rim lesions (PRL) are characterized by heterogeneous damage in multiple sclerosis (MS) patients. In this study we acquired in vivo, postmortem and histopathology with the aim to further characterize the microstructural properties of these lesions. Furthermore, we disentangled the heterogeneity of PRL by combining a stick-ball-sphere diffusion model with the quantification of mean T1 relaxation times.

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