Abstract #2816

Beyond the Mean: Myelin Heterogeneity Index as a Sensitive Metric for Assessing Myelin Damage in Multiple Sclerosis

Poljanka Johnson¹, Irene M Vavasour², Shawna Abel¹, Lisa E Lee³, Stephen Ristow¹, Cornelia Laule⁴, Roger Tam², David K.B. Li², Nathalie Ackermans¹, Alice Schabas¹, Jillian Chan¹, Helen Cross¹, Ana-Luiza Sayao¹, Virginia Devonshire¹, Robert Carruthers¹, Anthony Traboulsee³, and Shannon Kolind⁵

¹Medicine, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Radiology, Physics and Astronomy, Pathology, University of British Columbia, Vancouver, BC, Canada, ⁵Medicine, Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada

Myelin water imaging is a quantitative MRI technique that has been used to investigate myelin content in multiple sclerosis (MS). Three metrics derived from myelin water imaging were compared in the normal appearing white matter of different MS subtypes and correlations with disability were investigated. The myelin heterogeneity index was best able to distinguish between MS subtypes and demonstrated the strongest correlation with disability.

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