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Abstract #2816

Beyond the Mean: Myelin Heterogeneity Index as a Sensitive Metric for Assessing Myelin Damage in Multiple Sclerosis

Poljanka Johnson1, Irene M Vavasour2, Shawna Abel1, Lisa E Lee3, Stephen Ristow1, Cornelia Laule4, Roger Tam2, David K.B. Li2, Nathalie Ackermans1, Alice Schabas1, Jillian Chan1, Helen Cross1, Ana-Luiza Sayao1, Virginia Devonshire1, Robert Carruthers1, Anthony Traboulsee3, and Shannon Kolind5
1Medicine, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4Radiology, Physics and Astronomy, Pathology, University of British Columbia, Vancouver, BC, Canada, 5Medicine, Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada

Myelin water imaging is a quantitative MRI technique that has been used to investigate myelin content in multiple sclerosis (MS). Three metrics derived from myelin water imaging were compared in the normal appearing white matter of different MS subtypes and correlations with disability were investigated. The myelin heterogeneity index was best able to distinguish between MS subtypes and demonstrated the strongest correlation with disability.

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