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Abstract #2818

High-b Diffusivity of MS Lesion in Cervical Spinal Cord using Ultrahigh-b DWI (UHb-DWI)

Kyle Jeong1, Lubdha Shah2, You-Jung Lee1, Bijaya Thapa1, Nabraj Sapkota1, Erica Bisson3, Noel Carlson4, Eun-Kee Jeong2, and John Rose5
1Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 2Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 3Neurosurgery, University of Utah, Salt Lake City, UT, United States, 4GRECC, Veterans Affairs, Salt Lake City, UT, United States, 5Neuroimmunology and Neurovirology Division, University of Utah, Salt Lake City, UT, United States

Ultrahigh-b radial DWI (UHb-rDWI) is a technique that can quantitatively evaluate MS lesions with respect to degrees of demyelination and axonal damage and/or loss. Currently, there is a lack of sensitive diagnostic technique to quantitatively and non-invasively grade cervical spinal cord (CSC) injury and repair. Our UHb-rDWI can potentially be a powerful tool to quantitatively observe disease progression and monitor treatment responses in MS CSC. Therefore, the main objective of this study was to investigate UHb-rDWI signal in white matter tracts of the CSC and compare quantitative values between healthy control WM with both MS NAWM and WM lesions.

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