Abstract #2820

Myelin Water Imaging Demonstrates Myelin Loss in Multiple Sclerosis Normal Appearing White Matter over Two Years

Irene Margaret Vavasour¹, Poljanka Johnson², Shawna Abel³, Stephen Ristow³, Jared Splinter³, Cornelia Laule^1,4,5,6, Roger Tam¹, David KB Li¹, Nathalie Ackermans³, Alice J Schabas³, Jillian Chan³, Helen Cross³, Ana-Luiza Sayao³, Virginia Devonshire³, Robert Carruthers³, Anthony Traboulsee³, and Shannon H Kolind^1,3,4,6

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Neuroscience, University of British Columbia, Vancouver, BC, Canada, ³Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁵Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada

Therapies that target remyelination are under development and a non-invasive specific and sensitive imaging biomarker to evaluate their efficacy within the timescale of a clinical trial is vital. Using myelin water imaging, we followed a group of relapsing-remitting and progressive multiple sclerosis (MS) participants and healthy controls over approximately 2 years to compare their rate of change in myelin water fraction. A significant decrease in mean myelin water fraction was found over 2 years in the normal-appearing white matter of participants with MS, with a larger decrease in relapsing-remitting MS than progressive MS.

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