Abstract #2822

Quantitative multi-modal MRI shows correlations between lesion iron deposition and neuro-axonal density in progressive multiple sclerosis

Sara Collorone¹, Marco Battiston¹, Ferran Prados ^1,2,3, Alberto Calvi¹, Baris Kanber⁴, Francesco Grussu^1,5, Marios Yiannakas¹, Carmen Tur^1,6, Rebecca Samson¹, Olga Ciccarelli^1,7, and Claudia A.M. Gandini Wheeler-Kingshott^1,8,9

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, ²Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ³Universitat Oberta de Catalunya, Barcelona, Spain, ⁴Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London(UCL), London, United Kingdom, ⁵Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, ⁶Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, ⁷University College London Hospitals, Biomedical Research Centre, National Institute for Health Research, London, United Kingdom, ⁸Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, ⁹Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy

We present preliminary results on ten patients with progressive multiple sclerosis(PMS) who underwent multi-modal MRI including quantitative magnetisation transfer (qMT), relaxometry and neurite orientation dispersion and density imaging (NODDI). We obtained metrics sensitive to iron deposition (T2*), myelin (restricted proton fraction (F)), and neuro-axonal density (neurite density index (NDI)) in lesions and brain tissues. Increased lesion T2* was related to decreased NDI in lesions and cortical grey matter. The lesion high T2* and low NDI were related to worse cognitive performance. In PMS, iron deposition from innate immune activity may lead to axonal loss and represent a future therapeutic target.

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