Multiple Sclerosis (MS) includes both inflammatory demyelination and axonal degeneration, which may affect the tissue water fractions of brain parenchyma in both myelin and the CSF water compartments. Quantification of brain parenchyma CSF fraction (CSFF) may help us better understanding of this complicated neurodegenerative disease. Aging is the most common cause of neurodegenerations. Here we tested CSFF in a 111 non-active MS cohort (age:45-79 years) by using the multi-echo T2 relaxometry-based multiple water-compartment method. Multivariate multiple regression shows that in cortical gray matter CSFF increases with age by controlling other factors including gender, disease duration, and MS lesion burden.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords