Meeting Banner
Abstract #2833

Are Cramér-Rao Lower Bounds an Accurate Estimate for Standard Deviations in Magnetic Resonance Spectroscopy?

Karl Landheer1 and Christoph Juchem1,2
1Biomedical Engineering, Columbia University, New York City, NY, United States, 2Radiology, Columbia University, New York City, NY, United States

Cramér-Rao Lower Bounds (CRLBs) have become the routine method to approximate standard deviations for magnetic resonance spectroscopy. CRLBs are theoretically a lower bound on the standard deviation. Realistic synthetic 3 Tesla spectra were used to investigate the relationship between estimated CRLBs, true CRLBs and standard deviations. It was demonstrated that although the CRLBs are theoretically truly a lower bound on the standard deviation this approximation is valid only as long as the model properly characterizes the data. In the case when the basis set deviates from the measured data it was shown that the CRLBs deviate substantially from standard deviations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here