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Abstract #2860

Towards direct neuronal-current MRI: a novel statistical processing technique for measurements in the presence of system imperfections.

Chiara Coletti1, Sebastian Domsch1, Frans Vos1, and Sebastian Weingärtner1
1Imaging Physics, TU Delft, Delft, Netherlands

Functional imaging based on detection of neuronal currents using spin-lock prepared MRI may overcome limitations inherent to haemodynamic fMRI with BOLD. However, in-vivo application is hindered by system imperfections. In this work, the effects of B0 and B1+ inhomogeneities and background noise on neuro-current MRI signals are quantified. Furthermore, a new statistical data-processing technique based on the analysis of signal variability, SVarM, is proposed for neuro-current MRI time series. SVarM achieves overall higher sensitivity than existing data-processing methods and is shown to be more robust in the presence of system imperfections.

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