Abstract #2869

Comparison of Region-Wise and Voxel-Wise Diffusion Signal Harmonisation via Z-scoring and ComBat

Stefan Winzeck^1,2, Maíra Siqueira Pinto³, Virginia F. J. Newcombe², Ben Glocker¹, David K. Menon², and Marta M. Correia⁴

¹BioMedIA, Department of Computing, Imperial College London, London, United Kingdom, ²Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ³Universitair Ziekenhuis Antwerpen, Antwerp, Belgium, ⁴MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

This study compares the impact of voxel-wise versus region-wise harmonisation of diffusion-weighted imaging (DWI) signal via Z-scoring and ComBat. Both approaches and algorithms were shown equally effective in significantly reducing the variation in regionally observed FA and MD in a multi-acquisition DWI dataset.

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