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Abstract #2869

Comparison of Region-Wise and Voxel-Wise Diffusion Signal Harmonisation via Z-scoring and ComBat

Stefan Winzeck1,2, Maíra Siqueira Pinto3, Virginia F. J. Newcombe2, Ben Glocker1, David K. Menon2, and Marta M. Correia4
1BioMedIA, Department of Computing, Imperial College London, London, United Kingdom, 2Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 3Universitair Ziekenhuis Antwerpen, Antwerp, Belgium, 4MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom

This study compares the impact of voxel-wise versus region-wise harmonisation of diffusion-weighted imaging (DWI) signal via Z-scoring and ComBat. Both approaches and algorithms were shown equally effective in significantly reducing the variation in regionally observed FA and MD in a multi-acquisition DWI dataset.

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