Abstract #2891

Optimization of a multi-dose ferumoxytol-enhanced T1 MRI protocol for estimation of fractional myocardial blood volume

Caroline Colbert^1,2,3, Michael A. Thomas^3,4, Ran Yan^2,5, Hengjie Liu^1,2, Peng Hu^1,2,5, and Kim-Lien Nguyen^1,2,3

¹Physics and Biology in Medicine Graduate Program, UCLA David Geffen School of Medicine, Los Angeles, CA, United States, ²Department of Radiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States, ³Division of Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States, ⁴Department of Radiology, Northwestern School of Medicine, Chicago, IL, United States, ⁵Department of Bioengineering, UCLA Samueli School of Engineering, Los Angeles, CA, United States

We aimed to evaluate the feasibility of an abbreviated MRI protocol for estimation of fractional myocardial blood volume (fMBV). Four normal swine were imaged with the MOLLI sequence at baseline and following seven ferumoxytol doses. We estimated fMBV using our full dataset, after application of retrospective dose under-sampling, and with the fast-exchange approximation. A four-acquisition protocol with compartmental modelling may have potential to accurately estimate fMBV in studies of myocardial perfusion.

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