Abstract #2916

High Resolution Functional Mapping of Orientation Domains in the Cat Visual Cortex using Denoising with NORDIC

Shinho Cho¹, Steen Moeller¹, Mehmet Akçakaya², Logan Dowdle¹, Luca Vizioli¹, Djaudat Idiyatullin¹, Wei Chen¹, and Kâmil Uğurbil¹

¹Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Center for Magnetic Resonance Research and Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States

Animal model studies in functional brain imaging (fMRI) require extremely high spatial resolutions, thus being challenged by the low signal-to-noise ratio (SNR). Recent advances in fMRI denoising provide gains by suppressing thermal noise. Here we demonstrate significant improvements of fMRI results by NORDIC (NOise reduction with DIstribution Corrected PCA) de-noising; increased functional CNR and T-statistics, yielded the high signal stability of single fMRI acquisition with reproducible quantification of brain responses.

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