Regression of the BOLD “global signal” in human rs-fMRI studies to reduce widespread noise is a controversial practice since the signal may also contain neural activity. Rodent rs-fMRI studies offer an opportunity to better disentangle the neural and nonneural contributors to the global signal. However, global signal in rodents has been relatively little studied. We performed a voxel-wise analysis to examine the global signal’s spatial distribution. We found that, as in humans, global signal contributions vary spatially within the rat brain and that certain attributes of this signal are unique to the brain when compared to nonneural sources of noise.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords