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Abstract #2927

MRI based retinotopy of the rat visual pathway

Joana Carvalho1, Francisca F. Fernandes1, and Noam Shemesh1
1Champalimaud Centre for the Unknown, Lisbon, Portugal

Unravelling the fine-grained organization of the visual system is essential for understanding the foundations of vision in health and disease. Receptive field (RF) properties and retinotopic maps across the visual pathway were estimated non-invasively at unprecedented resolution, for the first-time in rodents. We tailored a set-up to deliver complex stimuli in preclinical scanners, and combined BOLD-fMRI with biologically-inspired models to investigate how RFs vary across cortical depth and hierarchy. We show that Lateral Geniculate Nucleus (LGN), Visual Cortex (VC) and Superior Colliculus (SC) are retinotopically organized and that RF sizes vary across cortical layers, spiking at layers IV and VI.

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