Abstract #2941

Optogenetic fMRI interrogation of the olfactory system

Teng Ma^1,2,3, Xunda Wang^1,2, Eddie C. Wong^1,2, Pit Shan Chong⁴, Sanchal Sanchayyan⁴, Lee Wei Lim⁴, Pek-Lan Khong³, Ed X. Wu^1,2, and Alex T. L. Leong^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, ³Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, ⁴School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

The olfactory system is one of the major sensory systems and has been often linked to numerous non-olfactory regions pivotal for sensory perception and higher-order cognition. However, the extent of where olfactory signals are distributed brain-wide remains poorly described. By optogenetically stimulating the excitatory projection neurons in olfactory bulb (OB), we interrogated the brain-wide functional organization of the olfactory system using fMRI. We revealed that OB neural activity propagated to regions that are associated with higher-order cognition, reward-related behaviors and multisensory processing.

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