Abstract #2946

Relaxation Time Mapping of Knee Articular Cartilage Using Magnetic Resonance Fingerprinting

Sanam Assili¹, Victor Casula^1,2, Jaakko Ikäheimo¹, Egor Panfilov¹, Ari Väärälä¹, Martijn A. Cloos³, Riccardo Lattanzi⁴, and Miika T. Nieminen^1,2,5

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, ³Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia, ⁴Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY, United States, ⁵Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Knee osteoarthritis is a degenerative musculoskeletal disorder which is characterized by progressive damage of articular cartilage (AC). Quantitative MRI (qMRI), such as T1 and T2 maps, can be used to assess the AC compositional changes. However, long acquisition time and equipment dependency are the limitations of the current clinical qMRI techniques. In the present study, we validate magnetic resonance fingerprinting (MRF) against conventional T1 and T2 relaxation time mapping methods in cartilage-mimicking phantoms, and apply MRF in vivo for sub-regional analysis of femoral and tibial cartilage in human subjects.

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