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Abstract #2946

Relaxation Time Mapping of Knee Articular Cartilage Using Magnetic Resonance Fingerprinting

Sanam Assili1, Victor Casula1,2, Jaakko Ikäheimo1, Egor Panfilov1, Ari Väärälä1, Martijn A. Cloos3, Riccardo Lattanzi4, and Miika T. Nieminen1,2,5
1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia, 4Center for Advanced Imaging Innovation and Research, New York University Grossman School of Medicine, New York, NY, United States, 5Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Knee osteoarthritis is a degenerative musculoskeletal disorder which is characterized by progressive damage of articular cartilage (AC). Quantitative MRI (qMRI), such as T1 and T2 maps, can be used to assess the AC compositional changes. However, long acquisition time and equipment dependency are the limitations of the current clinical qMRI techniques. In the present study, we validate magnetic resonance fingerprinting (MRF) against conventional T1 and T2 relaxation time mapping methods in cartilage-mimicking phantoms, and apply MRF in vivo for sub-regional analysis of femoral and tibial cartilage in human subjects.

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