Abstract #2954

Examining short-term longitudinal and activity-based variability of femoral cartilage T2 relaxation times in healthy subjects

Lauren Watkins^1,2, Andrew Schmidt¹, Elka Rubin¹, Marco Barbieri¹, Arjun Desai^1,3, Valentina Mazzoli¹, Marianne Black¹, Garry Gold^1,2, Brian Hargreaves^1,2,3, Akshay Chaudhari^1,4, and Feliks Kogan¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Bioengineering, Stanford University, Stanford, CA, United States, ³Electrical Engineering, Stanford University, Stanford, CA, United States, ⁴Biomedical Data Science, Stanford University, Stanford, CA, United States

Subtle variations in T2 relaxation times may be related to the risk of early osteoarthritis and progression. It is important to estimate T2 variability in healthy individuals as a basis for cross-sectional and longitudinal comparisons. We examine short-term T2 variability in femoral articular cartilage of healthy volunteers over 5 days and 5 weeks and consider the impacts of physical activity. Over both periods, mean T2 change, variance, and CV_RMS were small and comparable between knees and cartilage subregions. There was a moderate positive correlation between T2 changes and weekly rated perceived exertion over 5 weeks

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