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Abstract #2965

Deep, intermediate and superficial layers of patella cartilage assessment using T2 mapping in patients with chondromalacia.

Elena Voronkova1,2, Petr Menshchikov3,4, Ilya Melnikov1, Andrei Manzhurtsev1,4, Maxim Ublinskii1,4, Denis Vorobyev1, Dmitriy Kupriyanov3, and Tolib Akhadov1
1Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 2National Research Nuclear University MEPhI, Moscow, Russian Federation, 3Philips Healthcare, Moscow, Russian Federation, 4Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation

In this work, the values of the transverse relaxation times (T2) were measured for the first time in the deep, intermediate, and superficial layers of the patellar cartilage at different stages of chondromalacia as compared to control. The T2 values in the intermediate layer of cartilage show the best sensitivity to the grade of injury and have statistically significant differences for the groups of normal, mild, and severe cartilage damage. The T2-mapping technique is a potential tool for studying structural changes in cartilage and T2 values can be considered as a non-invasive biomarker for the assessment of the cartilage condition.

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