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Abstract #2967

Automated Pipeline for Quantitative MRI Evaluation of Knee Articular Cartilage in Longitudinal Osteoarthritis Trials

Vladimir Juras1, Veronika Janáčová1, Pavol Szomolanyi1, Markus Schreiner2, Didier Laurent3, Celeste Scotti3, and Siegfried Trattnig1
1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria, 3Novartis Institutes for Biomedical Research, Basel, Switzerland

The purpose of this study was to develop a fully automated reproducible tool for analysis of morphological and compositional quantitative MR parameters in well-defined cartilage sub-fields across the human knee. This tool was deployed to proton and sodium MR images and the reproducibility was assessed by test re-test scan of ten patients at baseline and after eight days. Due to high reproducibility found in this study this tool may be considered as a good alternative to manual evaluation which, as being extremely expertise-dependent and time-consuming, could represents a considerable burden for large clinical osteoarthritis trials.

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