A major challenge in the use of quantitative magnetization transfer (qMT) is the long scan time. One method to reduce scan time is acquiring fewer MT-weighted images. qMT mapping of the meniscus was performed in six cadaver knees. Fitting was repeated after systematically decreasing the number of input scans and comparing the results to a reference dataset (10 MT-weighted images). A set of eight MT-weighted images fit to a two-pool model with Gaussian lineshape was found to have an acceptable level of agreement (a priori of 10%) with the reference dataset, saving approximately 8 minutes in scan time.
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