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Abstract #2978

Quantitative Magnetization Transfer in the Knee Meniscus: Minimizing Data Collection Protocols

Fatemeh Mostafavi1, Lumeng Cui1, Brennan Berryman2, Ives R. Levesque3, and Emily J. McWalter1,2
1Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 2Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3McGill University, Montreal, QC, Canada

A major challenge in the use of quantitative magnetization transfer (qMT) is the long scan time. One method to reduce scan time is acquiring fewer MT-weighted images. qMT mapping of the meniscus was performed in six cadaver knees. Fitting was repeated after systematically decreasing the number of input scans and comparing the results to a reference dataset (10 MT-weighted images). A set of eight MT-weighted images fit to a two-pool model with Gaussian lineshape was found to have an acceptable level of agreement (a priori of 10%) with the reference dataset, saving approximately 8 minutes in scan time.

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