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Abstract #3014

Neuromelanin Sensitive MRI and QSM of the Substantia Nigra in Parkinson’s-Linked Asian LRRK2 Carriers

Septian Hartono1,2, An Sen Tan3, Weiling Lee4, Joey Oh4, Kuan Jin Lee5, Jongho Lee6, Eng King Tan1,2, and Ling Ling Chan2,4
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore, 4Singapore General Hospital, Singapore, Singapore, 5Singapore BioImaging Consortium, Singapore, Singapore, 6Seoul National University, Seoul, Korea, Republic of

Asian-specific leucine-rich repeat kinase 2 (LRRK2) gene risk variants are associated with increased risk of idiopathic Parkinson’s disease (PD) and accelerated motor progression in disease. We examined the role of quantitative susceptibility mapping (QSM) and neuromelanin-sensitive MRI (NMS) in quantifying dopaminergic denervation in the substantia nigra (SN) in LRRK2 risk-carriers and non-carriers in PD. QSM susceptibility and high-iron area in the SN were significantly increased in PD risk-carriers compared to non-carriers; NMS showed no difference between these two groups. Combined quantitative QSM models displayed good classification performance discriminating risk-carrier from non-carrier groups (68.4% sensitivity, 92.3% specificity, AUC 0.804) in PD.

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