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Abstract #3047

High-resolution T2 maps of the whole brain at 7 Tesla: a proof of concept study using adiabatic T2-prepared FLASH and compressed sensing

Gabriele Bonanno1,2,3, Patrick Leibig4, Tobias Kober5,6,7, and Tom Hilbert5,6,7
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland, 3Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 4Siemens Healthcare GmbH, Erlangen, Switzerland, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 7LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

T2 relaxometry has the potential to become an important quantitative MRI biomarker thanks to its sensitivity to pathology. However, acquiring high-resolution isotropic T2 maps is challenging due to signal-to-noise and specific absorption rate constraints. We present a T2-mapping method for ultra-high-field MRI based on an optimized T2-prepared acquisition with compressed sensing acceleration. The T2 preparation uses adiabatic pulses in conjunction with a segmented FLASH sequence to obtain uniform whole-brain T2 weighting despite B1 inhomogeneity. Preliminary tests show good signal homogeneity for images and maps obtained in a scan time compatible with volunteer studies.

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