Abstract #3047

High-resolution T2 maps of the whole brain at 7 Tesla: a proof of concept study using adiabatic T2-prepared FLASH and compressed sensing

Gabriele Bonanno^1,2,3, Patrick Leibig⁴, Tobias Kober^5,6,7, and Tom Hilbert^5,6,7

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ³Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ⁴Siemens Healthcare GmbH, Erlangen, Switzerland, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁷LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

T₂ relaxometry has the potential to become an important quantitative MRI biomarker thanks to its sensitivity to pathology. However, acquiring high-resolution isotropic T₂ maps is challenging due to signal-to-noise and specific absorption rate constraints. We present a T₂-mapping method for ultra-high-field MRI based on an optimized T₂-prepared acquisition with compressed sensing acceleration. The T₂ preparation uses adiabatic pulses in conjunction with a segmented FLASH sequence to obtain uniform whole-brain T₂ weighting despite B₁ inhomogeneity. Preliminary tests show good signal homogeneity for images and maps obtained in a scan time compatible with volunteer studies.

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