Abstract #3075

High spatial and temporal resolution rapid 3D IR-radFLASH pulse sequence for T1 mapping in the brain

Zhitao Li^1,2, Zhiyang Fu³, and Maria I Altbach⁴

¹Department of Radiology, Stanford University, Palo Alto, CA, United States, ²Electrical Engineering, Stanford University, Palo Alto, CA, United States, ³Electrical and Computer Engineering, The University of Arizona, Tucson, AZ, United States, ⁴Department of Medical Imaging, The University of Arizona, Tucson, AZ, United States

A 3D IR-radFLASH pulse sequence and a corresponding model-based reconstruction algorithm is presented for in vivo brain T₁ mapping. The proposed pulse sequence can acquire data for high SNR 1.0mm isotropic resolution T₁mapping within clinical time constraints. The proposed model-based reconstruction algorithm can reconstruct the acquired data with high temporal resolution, which can be used to map spin species with relatively low T₁ values. When combined with a slab-selective inversion pulse, the proposed technique can achieve whole brain coverage under 5 minutes.

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