Transverse relaxation (T2) mapping from standard images is investigated in human brain using only a proton density and T2-weighted dual-echo turbo spin echo acquisition and applying Bloch fitting approach with transmit field map. In 24 subjects, repeatability of T2 maps was excellent with typically coefficient of variation (CoV) ~1% on the same scanner. In grey and white matter overall, CoV was 0.4%. The method is then applied to study T2 changes across the lifespan from 5-90 years old in 333 healthy participants, providing a normative population of true T2 values independent of refocusing flip angle effects.
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