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Abstract #3080

Robust T2 Mapping from Standard Brain Images: Repeatability and Lifespan Changes in Healthy Participants

Peter Seres1, Kelly C McPhee1,2, Emily Stolz1, Julia Rickard1, Jeff Snyder1, Christian Beaulieu1, and Alan H Wilman1
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2CancerCare Manitoba, Winnipeg, MB, Canada

Transverse relaxation (T2) mapping from standard images is investigated in human brain using only a proton density and T2-weighted dual-echo turbo spin echo acquisition and applying Bloch fitting approach with transmit field map. In 24 subjects, repeatability of T2 maps was excellent with typically coefficient of variation (CoV) ~1% on the same scanner. In grey and white matter overall, CoV was 0.4%. The method is then applied to study T2 changes across the lifespan from 5-90 years old in 333 healthy participants, providing a normative population of true T2 values independent of refocusing flip angle effects.

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