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Abstract #3171

Interleaved multi-voxel 1H and 31P MRS for dynamic pH monitoring in the exercising calf muscle at 3 T with dynamic water reference.

Alfredo Liubomir Lopez Kolkovsky1,2, Beatrice Matot1,2, Eric Giacomini1, Martin Meyerspeer3, Benjamin Marty1,2, and Harmen Reyngoudt1,2
1NMR Laboratory, Institute of Myology, Paris, France, 2NMR Laboratory, CEA\DRF\IBFJ\MIRCen, Paris, France, 3High Field MR Center, CMPBME, Medical University of Vienna, Vienna, Austria

We extended an interleaved 1H/31P multi-voxel sequence for simultaneous pH monitoring based on carnosine (pH1H, PRESS) and Pi (pH31P, semi-LASER) with a co-localized dynamic water reference (PRESS). Simultaneous pH evaluations were done at 3 T in the soleus and gastrocnemius muscles during a straight-leg plantar flexion paradigm. A pH1H bias of ~0.05 units was removed by using the dynamic water reference. pH1H and pH31P time courses (1-minute temporal resolution) were comparable. Pi and Carnosine (C2-H) resonances broadened during exercise in the gastrocnemius. This method opens the way for new applications in functional studies targeting individual muscles at 3 T.

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