Abstract #3171

Interleaved multi-voxel 1H and 31P MRS for dynamic pH monitoring in the exercising calf muscle at 3 T with dynamic water reference.

Alfredo Liubomir Lopez Kolkovsky^1,2, Beatrice Matot^1,2, Eric Giacomini¹, Martin Meyerspeer³, Benjamin Marty^1,2, and Harmen Reyngoudt^1,2

¹NMR Laboratory, Institute of Myology, Paris, France, ²NMR Laboratory, CEA\DRF\IBFJ\MIRCen, Paris, France, ³High Field MR Center, CMPBME, Medical University of Vienna, Vienna, Austria

We extended an interleaved ¹H/³¹P multi-voxel sequence for simultaneous pH monitoring based on carnosine (pH_1H, PRESS) and Pi (pH_31P, semi-LASER) with a co-localized dynamic water reference (PRESS). Simultaneous pH evaluations were done at 3 T in the soleus and gastrocnemius muscles during a straight-leg plantar flexion paradigm. A pH_1H bias of ~0.05 units was removed by using the dynamic water reference. pH_1H and pH_31P time courses (1-minute temporal resolution) were comparable. Pi and Carnosine (C2-H) resonances broadened during exercise in the gastrocnemius. This method opens the way for new applications in functional studies targeting individual muscles at 3 T.

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