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Abstract #3174

Optimized water T2 mapping from multi-echo spin-echo acquisitions with an external fat fraction constraint

Francesco Santini1,2, Xeni Deligianni1,2, Matteo Paoletti3, Francesca Solazzo3, Matthias Weigel1,4,5, Paulo Loureiro De Sousa6, Oliver Bieri1,2, Mauro Monforte7, Enzo Ricci7,8, Giorgio Tasca7, Anna Pichiecchio3,9, and Niels Bergsland10,11
1Radiological Physics, Department of Radiology, University Hospital of Basel, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, 3Neurological Institute Foundation Casimiro Mondino (IRCCS), Pavia, Italy, 4Translational Imaging in Neurology, Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, 5Department of Neurology, University Hospital of Basel, Basel, Switzerland, 6UMR7357 Laboratoire des sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (ICube), Strasbourg, France, 7Institute of Neurology, A. Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy, 8Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy, 9Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 10Western New York Stem Cell Culture and Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY, United States, 11Fondazione Don Carlo Gnocchi Onlus (IRCCS), Milan, Italy

The measurement of the T2 of the water component is an important marker of neuromuscular diseases. Strategies exist to estimate it from conventional multi-echo spin-echo acquisitions, taking into account fat infiltration and B1 inhomogeneity. In this work, we present an open software that is able to efficiently perform this kind of fitting, and additionally to incorporate the information from an external fat fraction acquisition, for increased accuracy and reduced scan time.

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Abstract

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