Muscle T2 and fat-fraction are two promising metrics for sensitive measures of early disease-related changes in muscle for use in clinical trials. However, fat has a longer T2 than water in muscle and masks underlying increases in water T2 due to muscle oedema. The IDEAL-CPMG sequence with appropriate image-data processing produces a T2-water map uncontaminated by the fat signal. This sequence was acquired in healthy volunteers and two different muscular dystrophy disease types. It was found that elevated T2-water may be a predictor of later progression to fatty-atrophy in muscle, supporting the value of future longitudinal studies to test this.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords