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Abstract #3182

1H MRS: a tool to study age-related changes in intracellular metabolites in the deep spinal muscles?

Sarah Catherine Wayte1, Alexander Dallaway2, Andrew David Weedall1, John Hattersley3, and Adrian John Wilson3,4
1Radiology Physics, Department of Clinical Physics and Bioengineering, University Hospital, Coventry, United Kingdom, 2Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom, 3Coventry NIHR CRF, Human Metabolic Research Unit, University Hospital, Coventry, United Kingdom, 4Department of Physics, University of Warwick, Coventry, United Kingdom

1H MRS was used to investigate relative concentrations of methylene intracellular lipids [IMCLCH2]R and creatine [Cr]R in the psoas of groups of younger (19-30yrs) and older (61-81yrs) fit male volunteers. No difference was found between groups for either metabolite (p>0.05). However, the median value for [Cr]R in the older group (median;Q1-Q3=1.02;0.55-1.29%) was much higher than in the younger group (0.57;0.50-0.60%) suggesting [Cr]R could partially explain reduction in muscle strength with age being greater than predicted by loss of muscle mass. There was no correlation between metabolite concentrations (r2=0.21) so [Cr]R may possibly be a marker for age-related changes in muscle.

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