1H MRS was used to investigate relative concentrations of methylene intracellular lipids [IMCLCH2]R and creatine [Cr]R in the psoas of groups of younger (19-30yrs) and older (61-81yrs) fit male volunteers. No difference was found between groups for either metabolite (p>0.05). However, the median value for [Cr]R in the older group (median;Q1-Q3=1.02;0.55-1.29%) was much higher than in the younger group (0.57;0.50-0.60%) suggesting [Cr]R could partially explain reduction in muscle strength with age being greater than predicted by loss of muscle mass. There was no correlation between metabolite concentrations (r2=0.21) so [Cr]R may possibly be a marker for age-related changes in muscle.
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