This study aims to investigate whether human lumbar IDD can be detected using R2*, UTE-T2* and T1rho mapping. We systematically compared the efficacy of R2*, UTE-T2* and T1rho values in the diagnosis of early IDD. Specifically, we found that T1rho value is superior to UTE-T2* and R2* values for diagnosis of the early IVD, while UTE-T2* value is optimal for diagnosis of advanced IVD. Overall, we concluded that R2* and UTE-T2* mapping provides another promising method for quantitatively evaluated lumbar IDD, and T1rho mapping can be considered an effective tool for distinguishing IDD at earlier stage of the degenerative process
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