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Abstract #3190

Spinal Giant Cell Tumor of Bone: Immunohistochemistry and Preoperative Magnetic Resonance Imaging Features for Prognostic Prediction

Qizheng Wang1, Siyuan Qin1, Yang Zhang2, Enlong Zhang3, Xiaoying Xing1, Min-Ying Su2, and Ning Lang1
1Radiology, Peking University Third Hospital, Beijing, China, 2Center for Functional Onco-Imaging, Irvine, CA, United States, 3Radiology, Peking University International Hospital, Beijing, China

A new evaluating system based on tumor immunohistochemistry and preoperative MRI features in spinal giant cell tumor of bone to predicting overall survival of total en bloc spondylectomy patients with over 2 years follow up. The largest lesion diameter (>4.2 cm) and the vertebral compression were independent predictors of postoperative recurrence. According to Kaplan-Meier survival analysis, the cystic change in the lesion and the degree of compression ≥50% suggest a worse clinical outcome. The expression levels of vascular endothelial growth factor and p53 gene have no obvious clinical significance on the survival outcome. H3F3A was positively expressed in our cohort.

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