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Abstract #3239

Pulmonary Ventilation Analysis Using 1H Ultra-Short Echo Time (UTE) Lung MRI: A Reproducibility Study

Fei Tan1, Xucheng Zhu2, and Peder E.Z. Larson1,3
1Bioengineering, UC Berkeley - UCSF, San Francisco, CA, United States, 2GE Healthcare, Menlo Park, CA, United States, 3Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

In this abstract, we conducted a reproducibility study on the Jacobian determinant-based regional ventilation quantification of 1H phase-resolved ultrashort-echo (UTE) lung MRI. We evaluated its feasibility on five healthy adult volunteers and the influence of three registration approaches, cyclic registration, multi-b-spline, and symmetric image normalization (SyN). Regional ventilation maps of two scans, split violin plots of each individual’s regional ventilation distribution, within-subject coefficient of variation, and Bland-Altman plot and linear regression of total ventilation are presented. We demonstrated that Jacobian determinant ventilation quantification and the registration methods are reproducible and may be applied to patient studies in the future.

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