The study assessed the feasibility and image quality of free-breathing 3D isotropic whole-lung zero echo time (ZTE) imaging. The overall image quality of the lung in most healthy subjects was good to excellent. The visibility of pulmonary arteries (up to the 7th generation) was better than the bronchi (up to the 5th generation). The demonstration of fissures was poor. In addition, one volunteer with azygos fissure was discovered in our study, which encourage us promote ZTE as a routine lung examination tool. The whole lung ZTE with free-breathing is feasible and can serve as an alternative method of chest imaging.
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