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Abstract #3243

Pulmonary functional MR imaging with simultaneous multiple-breath washout tests

Anne-Christianne Kentgens1, Kathryn Ramsey1, Grzegorz Bauman2,3, Francesco Santini2,3, Christoph Corin Willers1, Philipp Latzin1, Oliver Bieri2,3, and Orso Pusterla2,3,4
1Division of Respiratory Medicine, Department of Pediatrics, Inselspital, University of Bern, Bern, Switzerland, 2Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, 3Department of Biomedical Engineering, University Hospital Basel, Basel, Switzerland, 4Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Simultaneous acquisition of oxygen-enhanced MRI and Multiple Breath Washout (MBW) testing is an unexplored and innovative methodology for lung function assessment. Until date, these techniques have been conducted separately. Combined use provides complementary and simultaneous information on pulmonary ventilation, diffusion and perfusion, and has several advantages compared to separate measurements. In this study, we performed oxygen-enhanced relaxometry and non-contrast enhanced ventilation and perfusion mapping using matrix pencil MRI, simultaneously with the MBW.

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