Abstract #3243

Pulmonary functional MR imaging with simultaneous multiple-breath washout tests

Anne-Christianne Kentgens¹, Kathryn Ramsey¹, Grzegorz Bauman^2,3, Francesco Santini^2,3, Christoph Corin Willers¹, Philipp Latzin¹, Oliver Bieri^2,3, and Orso Pusterla^2,3,4

¹Division of Respiratory Medicine, Department of Pediatrics, Inselspital, University of Bern, Bern, Switzerland, ²Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, ³Department of Biomedical Engineering, University Hospital Basel, Basel, Switzerland, ⁴Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Simultaneous acquisition of oxygen-enhanced MRI and Multiple Breath Washout (MBW) testing is an unexplored and innovative methodology for lung function assessment. Until date, these techniques have been conducted separately. Combined use provides complementary and simultaneous information on pulmonary ventilation, diffusion and perfusion, and has several advantages compared to separate measurements. In this study, we performed oxygen-enhanced relaxometry and non-contrast enhanced ventilation and perfusion mapping using matrix pencil MRI, simultaneously with the MBW.

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