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Abstract #3285

A method to rapidly quantify whole-organ metabolic rate of O2 with interleaved background-suppressed T2-oximetry and blood flow measurement

Rajiv S Deshpande1,2, Michael C Langham2, and Felix W Wehrli2
1Dept. of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Dept. of Radiology, University of Pennsylvania, Philadelphia, PA, United States

A T2-based oximetry pulse sequence has been developed by interleaving a phase-contrast module preceding a background-suppressed T2-prepared echoplanar imaging readout. The method enables rapid simultaneous measurement of blood flow velocity and T2 of blood water protons from a single anatomic location in 18 seconds scan time. The pulse sequence improves on T2-based oximetry methods, including T2-relaxation-under-spin-tagging (TRUST), by incorporating background-suppression to eliminate the need for “control” and “label” images. The pulse sequence also interleaves phase-contrast MRI so that a separate measurement of blood flow velocity is not required to quantify whole-organ metabolic rate of oxygen.

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