In this study, we aim to investigate the performance of quantitative measurements from synthetic MRI and DWI as well as their combinations in differentiating malignant from benign breast lesions and to compare with BI-RADS. Quantitative T2, PD and ADC values were significant lower in malignant than that of benign breast lesions. Quantitative multi-parameters of T2+PD+ADC had the best performance compared to all the other quantitative plans and BI-RADS. The approach, without contrast agents that combined synthetic MRI and DWI outperformed BI-RADS and may serve as an alternative and effective strategy for the improvement of breast lesion differentiation.
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