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Abstract #3294

Bias, repeatability and reproducibility of liver T1 mapping with variable flip angles

Sirisha Tadimalla1,2, Daniel J Wilson3, Margaret A Saysell4, Martin John Graves5, Iosif A Mendichovszky6,7, Geoffrey JM Parker8, and Steven Sourbron2,9
1Institute of Medical Physics, The University of Sydney, Sydney, Australia, 2Department of Biomedical Imaging Sciences, The University of Leeds, Leeds, United Kingdom, 3Department of Medical Physics and Engineering, Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom, 4Cardiac MRI, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5MR Physics and Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 6Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 7Department of Nuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 8Bioxydyn, Manchester, United Kingdom, 9Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

A multi-centre, multi-vendor study in 8 travelling healthy volunteers was conducted for technical validation of variable flip angle (VFA) T1 mapping in the liver across 6 scanners (3 vendors and 2 field strengths). The 95% CI was 28±8% for the bias in VFA liver T1, 10±3% for the intra-scanner repeatability CV and 28±6% for the inter-scanner reproducibility CV. These values are comparable to B1+ corrected VFA T1 in prostate, brain, and breast. Any proposed refinement of the VFA method in the liver should demonstrate a significant improvement on those benchmarks before it can be recommended as a future standard.

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