Meeting Banner
Abstract #3345

Cube set for the quantification of 3-dimensional spatial resolution in MR- micro imaging and microscopy (a = 128 - 4 µm) using 2-photon lithography

Andreas Georg Berg1,2, Stefan Hengsbach3, and Klaus Bade3
1Center for Medical Physics and Biomedical Engineering High field MR-Center, Medical University of Vienna, Vienna, Austria, 2High-Field MR-Center (MRCE), Medical Universits of Vienna, Vienna, Austria, 3Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology (KIT), Leopoldshafen-Eggenstein, Germany

Quality-control for systematic improvements in 3D-isotropic spatial resolution of the MR-imaging system up to the microscopic range becomes increasingly relevant not only for preclinical imaging but also for High-Field-MR human scanners. The design of a prototype phantom, comprising a set of 3D-cubes and an exemplary MR-microscopic evaluation is presented. The extraordinary challenges on accurate bar-width-to-cavity ratios for the cube range from periodicity a=128µm down to a=4µm are dealt with using 2-photon-lithography as manufacturing technology. The spatial resolution for 3D isotropic imaging can be checked qualitatively and quantitatively by interpolation of the Modulation-Transfer-Function demonstrated on a 3D-GRE sequence as an example.

This abstract and the presentation materials are available to members only; a login is required.

Join Here