Quality-control for systematic improvements in 3D-isotropic spatial resolution of the MR-imaging system up to the microscopic range becomes increasingly relevant not only for preclinical imaging but also for High-Field-MR human scanners. The design of a prototype phantom, comprising a set of 3D-cubes and an exemplary MR-microscopic evaluation is presented. The extraordinary challenges on accurate bar-width-to-cavity ratios for the cube range from periodicity a=128µm down to a=4µm are dealt with using 2-photon-lithography as manufacturing technology. The spatial resolution for 3D isotropic imaging can be checked qualitatively and quantitatively by interpolation of the Modulation-Transfer-Function demonstrated on a 3D-GRE sequence as an example.
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