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Abstract #3367

Investigating in-vivo function of Zebrin-II stripes of the cerebellum using tactile stimulation and prediction.

Lenno R. P. T. Ruijters1, Nikos Priovoulos1, and Wietske van der Zwaag1
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

The functional organization of the cerebellar cortex is largely unexplored in-vivo. However, connectivity studies suggest it is organized in successive Zebrin-II positive and negative stripes that receive descending signals from the cerebrum and ascending input from the peripheral nervous system respectively. To examine this stripe-based functional organization we used a tactile-stimulation experiment with actual (bottom-up) and predicted (top-down) stimulation at 7T. This paradigm gives reliable responses to predicted and experienced stimuli. Our fMRI results suggest that there is a spatial separation in the cerebellum between these two processes in line with the hypothesised relation between function and Zebrin-II stripes.

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