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Abstract #3374

Combining BOLD and CBV for enhanced fMRI CNR

An Thanh Vu1,2, Alexander JS Beckett3,4, Jennifer Townsend3,4, Salvatore Torrisi3,4, and David Feinberg3,4
1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2San Francisco Veteran Affairs Health Care System, San Francisco, CA, United States, 3Advanced MRI Technologies, Sebastopol, CA, United States, 4Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States

In this 7T study, we investigate the constructive combination of the BOLD and CBV weighted timeseries of EPI and GRASE based Vascular Space Occupancy (VASO) sequences for enhanced fMRI CNR. Activations from this BOLD+CBV combination resulted in 9% greater t-values as well as, on average, 39% more above-threshold voxels, relative to traditional BOLD. Although this combination method resulted in reduced microvascular specificity for EPI based VASO, for GRASE based VASO, the middle layers were predominantly enhanced, suggesting minimal loss in specificity. Advantageously, this technique does not require re-acquisition of data or modifications to pulse sequence parameters of the VASO sequence.

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