Abstract #3397

Modeling the vascular influences on BOLD fMRI using in vivo brain vasculature: incorporating vessel diameter, orientation, and susceptibility

Michael Bernier^1,2, Jeorg Peter Pfannmoeller^1,2, Saskia Bollmann³, Avery J.L. Berman^1,2, and Jonathan R Polimeni^1,2,4

¹Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ⁴Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States

We have developed a “forward-model” method to calculate the extravascular fields surrounding the blood vessels of the brain that accounts for the vessel diameter and orientation and estimates the field change with activation using in vivo measures of vessel anatomy and blood susceptibility.

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