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Abstract #3424

Mapping apparent soma and neurite density in the in-vivo mouse brain using SANDI

Andrada Ianus1, Francisca F. Fernandes1, Joana Carvalho1, Cristina Chavarrias1, Marco Palombo2, and Noam Shemesh1
1Champalimaud Centre for the Unknown, Lisbon, Portugal, 2University College London, London, United Kingdom

Measuring micro-architectural features involving cell body morphologies is emerging as a frontier of diffusion MRI. This work aimed to map the apparent soma size and density and neurite density via the SANDI methodology in the mouse brain in-vivo at 9.4T. Our results show consistent parameters values between N=3 animals in both gray and white matter ROIs. Moreover, we have also compared the effects of using different number of shells and maximum b-values in the SANDI analysis. Our work augurs well for future investigations in animal models of plasticity and disease.

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