Meeting Banner
Abstract #3429

Fast and accurate quantification of intra-voxel incoherent motion (IVIM) with spherical-tensor-encoded diffusion MRI

Alberto De Luca1,2, Geert-Jan Biessels1, Ofer Pasternak3, and Chantal MW Tax4,5
1Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands, 2PROVIDI Lab, Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 4Cardiff University Brain Research, Imaging Centre (CUBRIC), University of Cardiff, Cardiff, United Kingdom, 5Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Diffusion MRI scans sensitive to intra-voxel incoherent motion (IVIM) are increasingly being applied to derive properties of capillary blood pseudo-diffusion in-vivo. A robust quantification of pseudo-diffusion measures requires the acquisition of diffusion MRI with multiple weightings and directions, which is time-consuming. Here, we investigate whether the isotropic averaging of spherical tensor diffusion encoding (STE) can improve IVIM estimates and shorten the acquisition time. Our simulations and in-vivo data show that STE can substantially shorten the acquisition time required to robustly quantify pseudo-diffusion while also removing a previously unreported bias in voxels containing complex white matter fiber configurations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here