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Abstract #3432

Model-based reconstruction for IVIM and combined IVIM-DTI fitting: Initial experience

Susanne Rauh1, Oliver Maier2, Oliver Gurney-Champion3, Melissa Hooijmans3, Rudolf Stollberger2,4, Aart Nederveen3, and Gustav Strijkers1
1Department of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 2Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 3Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 4BioTechMed-Graz, Graz, Austria

Model-based reconstruction can overcome many short-comings of IVIM and DTI by accelerating the acquisition, suppressing systematic errors from Rician noise and improving SNR. In this study we assess the feasibility of model-based reconstruction to obtain IVIM and combined IVIM-DTI parameter maps in the liver and kidneys in healthy volunteers. Results were compared to a conventional IVIM and IVIM-DTI least-squares fitting. Model-based reconstructions produced maps with less artifacts in liver and more details in the kidneys as compared to those from conventional fitting. Mean parameter values were similar for both methods.

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