Abstract #3455

An optimized MP2RAGE sequence for studying both brain and cervical spinal cord

Arash Forodighasemabadi^1,2,3,4, Henitsoa Rasoanandrianina^1,2,3,4, Mohamed Mounir El Mendili^1,2, Maxime Guye^1,2, and Virginie Callot^1,2,4

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France, ³Aix-Marseille Univ, Université Gustave Eiffel, LBA, Marseille, France, ⁴iLab-Spine International Associated Laboratory, Montreal, Canada, Marseille, France

Magnetization Prepared 2 Rapid Acquisition Gradient Echo (MP2RAGE) is a T₁ mapping technique used broadly on brain and recently on spinal cord (SC).The growing interest for combined investigation of brain and SC brings about the need for optimization with regards to spatial coverage, high CNR, low B₁⁺ sensitivity, short acquisition time and high robustness.This work proposes an optimized sub-millimetric protocol for simultaneous brain and cervical spinal cord (BCSC) MP2RAGE acquisition at 3T and subsequent post-processing pipeline. It shows excellent agreement with previously proposed brain or SC protocols, with good reproducibility, which opens up great perspectives for clinical applications.

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