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Abstract #3462

Spinal cord perfusion mapping using Intra-Voxel Incoherent Motion at 3T in healthy individuals and Degenerative Cervical Myelopathy patients

Simon Lévy1,2,3, Patrick Freund4,5,6, Virginie Callot1,2,3, and Maryam Seif4,5
1CRMBM, Aix-Marseille University, CNRS, Marseille, France, 2CEMEREM, APHM, Hopital Universitaire Timone, Marseille, France, 3iLab-Spine International Research Laboratory, Marseille-Montreal, France, 4Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland, 5Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 6Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

In the search for a technique to assess spinal cord perfusion, the Intra-Voxel Incoherent Motion technique, previously implemented at 7T, was adapted to 3T. B-values were optimized based on phantom acquisitions. The final protocol was applied within 11 healthy volunteers and 2 Degenerative Cervical Myelopathy patients. The technique demonstrated sensitivity to perfusion in healthy volunteers and to capillary network orientations, with a clear depiction of the gray matter perfusion and inter-slice reproducibility. No significant difference could be shown between healthy volunteers and patients given the small sample size but more patients will be included in the near future.

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