A subset of nonfunctioning pituitary macroadenomas (NFPAs) may show early progression/recurrence (P/R) after surgery. In clinical practice, one of the main challenges in the treatment of NFPAs is to determine factors associated with P/R. This study investigated the role of preoperative MR radiomics based on support vector machine (SVM) for the prediction of P/R in NFPAs. The three most significant radiomic features selected by SVM were used to calculate SVM score for each patient. High SVM scores were associated with P/R and short progression-free survival in NFPAs.