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Abstract #3608

Altered T1 and T2 relaxation times in leg muscles are linked to hemodynamic and ambulatory parameters in patients with Peripheral Artery Disease.

Constance J Mietus1, Yue Gao1, Mariano G Uberti2, Nicholas G Lambert1, Panagiotis Koutakis3, Evlampia Papoutsi3, Jonathan R Thompson1, Holly K DeSpiegelaere4, Michael D Boska2, Sara A Myers5, George P Casale1, Iraklis I Pipinos1,4, and Balasrinivasa R Sajja2
1Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States, 2Department of Radiology, University of Nebraska Medical Center, Omaha, NE, United States, 3Department of Biology, Baylor University, Waco, TX, United States, 4Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States, 5Department of Biomechanics, University of Nebraska Omaha, Omaha, NE, United States

Understanding the quantitative MRI features of the myopathy of Peripheral Artery Disease (PAD) may aid in grading disease severity, treatment response, and potentially predicting favorable response to exercise or revascularization surgery. In this study we explored the relationship between T1 and T2 relaxation times and measurements of hemodynamic and ambulatory performance in patients with PAD. T1 relaxation time positively correlated with ankle brachial index and peak plantar flexion and inversely correlated with claudication onset time. T2 relaxation time correlated positively with peak plantar flexion and inversely correlated with ischemic window, claudication onset time, and peak walking time.

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