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Abstract #3611

Visualization of Coronary Myocardial Chemoablation: Comparison of Ethanol and Acetic Acid

Daniel A Herzka1, Rajiv A Ramasawny1, Chris G. Bruce1, Delaney R. McGuirt1, William H. Schenke1, Jaffar M. Khan1, Adrienne E. Campbell-Washburn1,2, Aravindan A Kolandaivelu1,3, Toby A Rogers1,4, and Robert J. Lederman1
1NHLBI, Division of Intramural Research, National Institutes of Health, Bethesda, MD, United States, 2Biophysics and Biochemistry Branch, Division of Intramural Research, NHLBI, NIH, Bethesda, MD, United States, 3Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Cardiology, Medstar Washington Hospital Center, Washington, DC, United States

In this work, we visualize chemoablation lesions created by intracoronary injection as used in alcohol septal ablation for the treatment of hypertrophic obstructive cardiomyopathy. 3D native contrast and gadolinium-enhanced MRI were examined. Two chemoablation agents were used: standard ethanol and a potential alternative agent, glacial acetic acid. In swine, both 3D native contrast and gadolinium-enhanced imaging clearly delineated lesion extent acutely and up to two weeks post ablation. Acutely, chemoablation with ethanol induced a 22% increase in T1 within lesion cores and acetic acid yielded a 36% decrease.

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Abstract