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Abstract #3621

Microstructure-Based Simulation of Myocardial Diffusion Using Extended Volume Confocal Microscopy

Alexander James Wilson1, Kevin M Moulin2, Gregory B Sands3, and Daniel B Ennis2
1Radiology, Stanford University, Palo Alto, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand

Aiming to improve noninvasive assessment of tissue microstructure, a physics-based simulation of diffusion tensor imaging (DTI) was used to compare helix angles between DTI and structure tensor (ST) analyses of a confocal myocardial image stack. Rodent myocardium was imaged using extended volume confocal microscopy producing a high-resolution image volume, which was segmented into intracellular and extracellular compartments. The image volume was divided into voxel-blocks, which served as the DTI simulation voxels. The DTI acquisition showed good agreement with both the ST and manually measured helix angles. This proof-of-concept work demonstrates the feasibility of direct comparison of confocal images with DTI.

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