Meeting Banner
Abstract #3651

Time-dependent anisotropic diffusion in the mouse heart: feasibility of motion compensated tensor-valued encoding on a 7T preclinical scanner

Samo Lasic1,2, Henrik Lundell1, Beata Wereszczyńska3, Matthew Budde4, Nadira Yuldasheva3, Filip Szczepankiewicz5, Erica Dall’Armellina3, Jürgen E. Schneider3, and Irvin Teh3
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 2Random Walk Imaging, Lund, Sweden, 3Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 4Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 5Clinical Sciences, Lund University, Lund, Sweden

Tensor-valued diffusion encoding with simultaneous nulling of velocity, acceleration and concomitant gradients can be applied with high b-values on a preclinical 7T scanner. Results for ex-vivo mouse hearts confirm that time-dependent diffusion can significantly affect estimation of mean diffusivity. The estimated restriction sizes are consistent with results from pig hearts. Signal attenuations at high b-values suggest relatively low microscopic anisotropy and a strong influence of time-dependent diffusion on microstructure characterization.

This abstract and the presentation materials are available to members only; a login is required.

Join Here