Abstract #3651

Time-dependent anisotropic diffusion in the mouse heart: feasibility of motion compensated tensor-valued encoding on a 7T preclinical scanner

Samo Lasic^1,2, Henrik Lundell¹, Beata Wereszczyńska³, Matthew Budde⁴, Nadira Yuldasheva³, Filip Szczepankiewicz⁵, Erica Dall’Armellina³, Jürgen E. Schneider³, and Irvin Teh³

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ²Random Walk Imaging, Lund, Sweden, ³Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ⁴Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Clinical Sciences, Lund University, Lund, Sweden

Tensor-valued diffusion encoding with simultaneous nulling of velocity, acceleration and concomitant gradients can be applied with high b-values on a preclinical 7T scanner. Results for ex-vivo mouse hearts confirm that time-dependent diffusion can significantly affect estimation of mean diffusivity. The estimated restriction sizes are consistent with results from pig hearts. Signal attenuations at high b-values suggest relatively low microscopic anisotropy and a strong influence of time-dependent diffusion on microstructure characterization.

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