Abstract #3651

Time-dependent anisotropic diffusion in the mouse heart: feasibility of motion compensated tensor-valued encoding on a 7T preclinical scanner

Samo Lasic^1,2, Henrik Lundell¹, Beata Wereszczyńska³, Matthew Budde⁴, Nadira Yuldasheva³, Filip Szczepankiewicz⁵, Erica Dall’Armellina³, Jürgen E. Schneider³, and Irvin Teh³

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ²Random Walk Imaging, Lund, Sweden, ³Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ⁴Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Clinical Sciences, Lund University, Lund, Sweden

Tensor-valued diffusion encoding with simultaneous nulling of velocity, acceleration and concomitant gradients can be applied with high b-values on a preclinical 7T scanner. Results for ex-vivo mouse hearts confirm that time-dependent diffusion can significantly affect estimation of mean diffusivity. The estimated restriction sizes are consistent with results from pig hearts. Signal attenuations at high b-values suggest relatively low microscopic anisotropy and a strong influence of time-dependent diffusion on microstructure characterization.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.