H3K27M mutant diffuse midline gliomas are a newly classified entity in the 2016 World health organization classification of CNS tumors. They are high grade tumors, with the mere presence of this mutation confers them a WHO grade IV designation, irrespective of their histologic morphology. Patients harboring these tumors have dismal prognosis and shorter overall survival. Furthermore, since these are deep-seated lesions involving the eloquent brain areas, biopsy can be challenging with substantial risk of morbidity. Our work proposes non-invasive multiparametric MRI-based imaging attributes to detect the H3K27M mutation pre-operatively. Results demonstrate a considerable accuracy on 123 patients.
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