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Abstract #3671

Imaging attributes of H3K27M mutation in Diffuse Midline Gliomas on Multiparametric MRI

Richa Singh Chauhan1, Nihar Kathrani2, Jitender Saini1, Maya D Bhat1, Karthik Kulanthaivelu1, Vani Santosh3, Nishanth S4, and Subhas Konar4
1Neuroimaging and Interventional Radiology, NIMHANS, BENGALURU, India, 2Interventional Radiology, Paras Hospital, Gurgaon, India, 3Neuropathology, NIMHANS, BENGALURU, India, 4Neurosurgery, NIMHANS, BENGALURU, India

H3K27M mutant diffuse midline gliomas are a newly classified entity in the 2016 World health organization classification of CNS tumors. They are high grade tumors, with the mere presence of this mutation confers them a WHO grade IV designation, irrespective of their histologic morphology. Patients harboring these tumors have dismal prognosis and shorter overall survival. Furthermore, since these are deep-seated lesions involving the eloquent brain areas, biopsy can be challenging with substantial risk of morbidity. Our work proposes non-invasive multiparametric MRI-based imaging attributes to detect the H3K27M mutation pre-operatively. Results demonstrate a considerable accuracy on 123 patients.

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